Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, ...

scPairs is an R package for the systematic identification and multi-evidence evaluation of synergistic gene pairs in single-cell and spatial transcriptomics data. Unlike conventional pairwise ...

4D-BioReconX is a scalable and versatile framework designed to construct a comprehensive four-dimensional (4D) spatial transcriptomics atlas of whole animals at single-cell resolution. This approach ...

Lymph nodes are key sites of adaptive immune responses, yet how immune cells coordinate their activities in space and time remains poorly understood. We combined high-resolution spatial ...

Background Most patients with biliary tract cancer (BTC) do not derive durable clinical benefit (DCB) from immune checkpoint inhibitors (ICIs), underscoring the urgent need for predictive biomarkers.

Abstract: Spatial transcriptomics (ST), known as an expensive medical examination, plays an important role in analyzing the spatial heterogeneity of tumors. When considering the correlation between ...

New research reveals that while losing weight can rejuvenate aging fat tissue, stubborn immune cells keep a “memory” of obesity, offering fresh targets for lasting metabolic health. Study: Selective ...

aDivision of Rheumatology, Department of Internal Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, 510630, China bDepartment of Endocrinology and Metabolism, ...

Osteoarthritis (OA), a debilitating joint disorder characterized by synovial inflammation and immune myeloid cell infiltration, currently lacks a comprehensive spatial and transcriptional atlas. This ...

More than half of patients with ischemic stroke experience futile reperfusion, increasing the risk of death and disabilities despite a successful recanalization. The reason behind this is debated, and ...