Over the past decade, Professor L. Mahadevan's Soft Math Lab at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has helped establish how the ancient Japanese paper arts ...
International authorities and a raft of private technology companies say they have disrupted a cybercrime “assembly line” ...
Glioblastoma (GBM) is a highly lethal malignancy driven by glioma-initiating cells (GICs). While GICs are known to profoundly remodel tumor microenvironment (TME) to promote progression and immune ...
Alternative splicing represents a critical layer of gene regulation that greatly diversifies the expression of transcript and protein isoforms from a limited repertoire of genes. Transcripts from over ...
Dependencies: python (inlcuding numpy, ete3, pandas, and intervaltree libraries), HMMER version 3, MAFFT. Wise2 is also required to use the "full_pseudoexon_search ...
The majority of immune-mediated disease (IMD) risk loci are located in non-coding regions of the genome, making it difficult to decipher their functional effects in relevant physiological contexts. To ...
PTBP1 Depletion in Mature Astrocytes Reveals Distinct Splicing Alterations Without Neuronal Features
This study reports important negative results by showing that genetic removal of the RNA-binding protein PTBP1 in astrocytes is not sufficient to induce their conversion into neurons, challenging ...
In this important study, the authors conducted atomistic molecular dynamics simulations to probe the interactions between IRE and unfolded peptides. The results help reconcile contradicting ...
Pulmonary artery endothelial cell (PAEC) dysfunction is a pathological hallmark of pulmonary hypertension (PH). Yet, the roles of long noncoding RNAs (lncRNAs) driven by super-enhancers (SEs) in PAECs ...
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