Despite the advent of “methylomic” analyses, bisulfite modification of genomic DNA followed by Sanger sequencing remains the most precise assay for investigating the methylation profile of specific ...

This repo contains a PyTorch implementation for the paper "Designing DNA With Tunable Regulatory Activity Using Discrete Diffusion". The training and sampling part of the code is inspired by Score ...

Trained on sequences of length 131k, with a model size of 256 and 16 layers. Trained for 50k steps and batch size of 8. Trained with reverse-complement (RC) data ...

Genetic variants across the genome contribute to complex human diseases and agricultural traits, but interpreting them can be challenging. We propose a genome-wide variant effect prediction approach ...

Direct sequencing of single molecules through nanopores allows for accurate quantification and full-length characterization of native RNA or complementary DNA (cDNA) without amplification. Both ...

Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that ...

Herbal drug authentication is an important task in traditional medicine; however, it is challenged by the limitations of traditional authentication methods and the lack of trained experts. DNA ...