Toolchains (Rustc, Cargo, libraries, etc.) Rustup (toolchain multiplexer) Crates.io (community-supplied Crates) with "sparse" index support. Incremental artifact downloading (with a configurable ...

Genome-wide chromosome conformation capture methods (such as Hi-C 1) revealed that mammalian genomes are folded into thousands of topologically associating domains (TADs) spanning 100–1,500 kb 2,3,4,5 ...

This article introduces a model-based design, implementation, deployment, and execution methodology, with tools supporting the systematic composition of algorithms from generic and domain-specific ...

This is a valuable study on DNA gyrase that provides further evidence for its mode of action via a double-stranded DNA break and against a recently-proposed alternative mechanism. The evidence ...

Despite the well-established role of nuclear organization in the regulation of gene expression, little is known about the reverse: how transcription shapes the spatial organization of the genome.

Department of Applied Physics and Applied Mathematics, Columbia University, New York, New York 10027, United States Condensed Matter Physics and Materials Science Department, Brookhaven National ...

Human genes can generate multiple protein isoforms by alternative splicing (AS) of different sets of pre-mRNA exons, which enables another layer of regulatory control over gene function in development ...

The human genome folds in 3 dimensions to form thousands of chromatin loops inside the nucleus, encasing genes and cis-regulatory elements for accurate gene expression control. Physical tethers of ...

The high-resolution structures presented herein explain how ERp44, a multifunctional chaperone cycling in the early secretory pathway, exploits the endoplasmic reticulum (ER)–Golgi pH gradient to bind ...