Tiny DNA 'hitchhikers' may be reshaping life in thawing Arctic soils

Amid the peatlands of northern Sweden, billions of microbes are quietly rewriting their genetic playbooks—and doing so far more often than scientists realized.
Genomics England

Genomic Data Scientist - Cancer (we have office locations in Cambridge, Leeds & London)

Job Description We are seeking a passionate and innovative Genomic Data Scientist to join our Bioinformatics Research ...
ITV

The latest ITV weather forecast for the UK

Today:Early fog in the far southwest clears quickly. Most areas stay dry with sunshine and variable cloud, though northern and northeastern regions may see isolated showers. Light winds overall, ...
GitHub

mergem is a python package and command-line tool for merging, comparing, and translating genome-scale metabolic models.

> mergem --help Usage: mergem [INPUT_FILENAMES] [OPTIONS] mergem takes genome-scale metabolic models as input, merges them into a single model and saves merged model as .xml. Users can optionally ...
Nature

Genome-scale metabolic modelling identifies reactions mediated by SNP-SNP interactions associated with yeast sporulation

Genome-scale metabolic models (GEMs) are powerful tools used to understand the functional effects of genetic variants. However, the impact of single nucleotide polymorphisms (SNPs) in transcription ...
The New England Journal of Medicine

Chemical Complexity of Food and Implications for Therapeutics

These epidemiologic patterns highlight the limitations of focusing on genetics alone. Although the Human Genome Project greatly expanded our understanding of hereditary contributions to disease, genes ...
C&EN

The Dawn of High-Throughput and Genome-Scale Kinetic Modeling: Recent Advances and Future Directions

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Researchers have invested much effort into developing kinetic models due to their ...
eLife

Somatic mutation rates scale with time not growth rate in long-lived tropical trees

Satake and colleagues' important study elucidates somatic mutation processes in plants, demonstrating that in two tropical trees, mutation rates correlate with age, not growth rates. Their convincing ...
The Lancet

Genome-wide enhancer-associated tandem repeats are expanded in cardiomyopathy

pDivision of Cardiology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada qDivision of Cardiology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada ...
ahajournals.org

Genome-Wide CRISPR Screen Identifies an NF2-Adherens Junction Mechanistic Dependency for Cardiac Lineage

Cardiomyocyte differentiation involves a stepwise clearance of repressors and fate-restricting regulators through the modulation of BMP (bone morphogenic protein)/Wnt-signaling pathways. However, the ...
GitHub

CobraMod: A pathway-centric curation tool for constraint-based metabolic models

CobraMod is a Python 3 open-source package for pathway-centric curation of genome-scale metabolic models (GEMs). It builds upon the COBRApy toolbox and offers a comprehensible set of functions for ...