Nature

Encoding hierarchical 3D architecture through inverse design of programmable bonds

The ability to fabricate materials and devices at small scales by design has resulted in tremendous technological progress. However, the need for engineered three-dimensional (3D) nanoscale materials ...
The Scientist

Glutamate Biosensors Illuminate Talk Between Neurons

Neurotransmitters are the words our brain cells use to communicate with one another. For years, researchers relied on tools that provided limited temporal and spatial resolution to track changes in ...
eLife

Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of ...
ahajournals.org

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin

Vascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding ...
C&EN

Robust Multichannel Encoding for Highly Multiplexed Quantitative PCR

Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Single-target quantitative polymerase chain reaction (qPCR) is ...
Frontiers

The Kinase Specificity of Protein Kinase Inhibitor Peptide

G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and ...
C&EN

Altering the Substrate Specificity of Acetyl-CoA Synthetase by Rational Mutagenesis of the Carboxylate Binding Pocket

Roy J. Carver Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States Engineering Research Center for Biorenewable Chemicals, Iowa State ...
The New England Journal of Medicine

A New Class of Medicines through DNA Editing

Genome editing is a set of methods used to change the DNA of a cell with single base-pair precision. It is a specific form of gene therapy, and the engineering of cells through genome editing has the ...
Frontiers

Modeling Semantic Encoding in a Common Neural Representational Space

Encoding models for mapping voxelwise semantic tuning are typically estimated separately for each individual, limiting their generalizability. In the current report, we develop a method for estimating ...
PNAS

Functional specificity in the human brain: A window into the functional architecture of the mind

Is the human mind/brain composed of a set of highly specialized components, each carrying out a specific aspect of human cognition, or is it more of a general-purpose device, in which each component ...
Nature

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers

T cells recognize virus-infected cells and tumor cells by detecting the presence of disease-specific peptide–major histocompatibility complexes (pMHC) with their clone-specific T-cell receptor. Both ...