When the first messenger RNA (mRNA) vaccines proved effective during COVID, many experts viewed them as a short-term fix. Five years later, the same technology evolved into one of medicine’s most ...

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Coronary atherosclerotic plaques susceptible to acute coronary syndrome have traditionally been characterized by their surrounding cellular architecture. However, with the advent of intravascular ...

Developmental programming involves the accurate conversion of signalling levels and dynamics to transcriptional outputs. The transcriptional relay in the Notch pathway relies on nuclear complexes ...

Pseudoknots are key structure motifs of RNA and pseudoknotted RNAs play important roles in a variety of biological processes. Here, we present KnotFold, an accurate approach to the prediction of RNA ...

Machine learning (ML) and in particular deep learning techniques have gained popularity for predicting structures from biopolymer sequences. An interesting case is the prediction of RNA secondary ...

Deep learning, or artificial neural networks, is a type of machine learning algorithm that can decipher underlying relationships from large volumes of data and has been successfully applied to solve ...

Omes and omics are proliferating these days: Genomics. Proteomics. Metabolomics. But what are they? What’s the point of ome-ing everything? An “ome” is a totality. So a genome is all the DNA, ...

Single-molecule FRET (smFRET) has become a mainstream technique for studying biomolecular structural dynamics. The rapid and wide adoption of smFRET experiments by an ever-increasing number of groups ...

Researchers have demonstrated a new approach to joining -- and reconfiguring -- modular DNA building units, by snapping together complementary shapes instead of zipping together strings of base pairs.

A pseudoknot forms in an RNA when nucleotides in a loop pair with a region outside the helices that close the loop. Pseudoknots occur relatively rarely in RNA but are highly overrepresented in ...

Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, and Department of Chemistry and Center for Biomolecular Sciences, Bowling ...