RNA interference is a natural mechanism for living cells to control whether specific genes are being used. Crowned with the ...

Enzymes are regarded as the key to sustainable chemistry. Despite major advances in protein design, creating artificial enzymes from scratch has so far remained a grand challenge. A research team at ...

Over the past two decades, high‑throughput sequencing has dramatically expanded our understanding of the gut microbiome's composition.

This fundamental work reveals that the accessibility of the unstructured C-terminal tails of α- and β-tubulins differs with the state of the microtubule lattice. Their accessibility increases with the ...

Natural products provide the inspiration for most drugs, and marine natural products, in particular, are emerging as promising new therapeutics with new targets or mechanisms of action.

Protein ubiquitination is a key post-translational modification regulating a wide range of biological processes. Ubiquitination involves the covalent attachment of the small protein ubiquitin to a ...

† Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K. ‡ Medicinal Chemistry, Department of Pharmacy and Pharmacology, ...